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KMID : 0360419940300010059
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Korean Journal of Pharmacology
1994 Volume.30 No. 1 p.59 ~ p.65
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Effect of Starvation on Contractility of Lidocaine-Depressed Isolated Rat Atria
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Ko Kye-Chang
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Abstract
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The experiments were performed to determine whether lidocaine interferes with the utilization of lipid as source of energy fuel for the contractile process by the isolated rat atria. Rats were starved for two days in order to inerease the lipid content of the heart. Atria from starved rats were better able to maintain their contractility in the absence of exgenous substrate, and also were more resistant to depression by lidocaine than atria from fed rats. Starvation results in a marked loss of body weight in rats. In contrast to the starved rats, the body weight of fed rats inereased with time. The smaller reduction in contractile activity of atria from the starved rats may suggest that endogenous lipid accumulates during starvation period and is used as an energy source for the contractile process in the face of a lidocaine-induced blockade in glycolysis.
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KEYWORD
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Lidocaine, Contractility, Heart, Starvation, Lipid
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